Welcome to
Overdose Lifeline
A nonprofit dedicated to helping individuals, families, and communities affected by substance use disorder. We work to prevent overdoses through education, preventative treatment, and by offering emergency services.
Substance Use Disorder Help When and Where It’s Needed
Overdose due to opioid use has become a leading cause of death in the US. Today, Americans are more likely to die due to an overdose than they are from cars and guns. Yet services, specifically those aimed at overdose prevention and substance use help, do not meet the growing opioid crisis.
Overdose Lifeline’s objective is not only to increase access to overdose prevention and education services but also to remove the stigma of addiction and provide proper care and access to treatment for those at risk.
Learn more about Substance Use Disorder and the overdose epidemic.
Why Overdose Prevention Matters

1 in 4
noncancer opioid users struggle with addiction
100,000+
overdose deaths in the US were estimated to have occurred in 2021
90 percent
of addictions have been proven to originate during the teenage years
Substance Use Disorder Prevention and Education Programs
Overdose Lifeline offers evidence-based programs for developing overdose prevention strategies that seek to address underlying problems, raise awareness and develop crucial support networks. Learn about some of our main programs and how to take part below.

Increasing Access to Overdose Prevention
Equal access to naloxone is a key step in fighting the opioid epidemic, providing lifesaving treatment for those who experience an overdose. Overdose Lifeline aims to reduce barriers to naloxone access.
Near Me
ODL Events & Trainings
Overdose reversal kit making – Volunteer event
Overdose Lifeline Office
1100 W 42nd St, Indianapolis, IN
Lifeline for Loss Support Group – Marion County
Indiana InterChurch Center
Indianapolis, IN
Overdose reversal kit making – Volunteer event
Overdose Lifeline Office
1100 W 42nd St, Indianapolis, IN
Overdose reversal kit making – Volunteer event
Overdose Lifeline Office
1100 W 42nd St, Indianapolis, IN
Essential News Posts

What is Xylazine and Why Should I Be Aware of It?
Overdose Lifeline strives to provide the most up-to-date, research-based information on overdose, drugs that can cause overdose, and overdose prevention. Xylazine, a non-opioid sedative used in veterinary medicine, has recently

Celebrating Julie and Paul
The Overdose Lifeline Board and Staff are thrilled to announce the official opening of the Heart Rock Justus Family Recovery Center. A recovery residence for women and women who are pregnant and parenting young children has been part of the ODL strategic plan since 2017. It is an honor and privilege to be fulfilling this vision

The Opioid Health Crisis
The U.S. is Facing a National Public Health Crisis Related to Prescription and Illicit Opioids As reported by the Centers for Disease Control (CDC). Read more about the history of Opioids and how the crisis has affected our nation at large.
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