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Naloxone (Narcan™) is a medication designed to reverse an opioid overdose during an emergency situation. Eliminating barriers to receiving naloxone has been one of Overdose Lifeline’s primary missions since its inception.

Why is naloxone important?


Naloxone has been instrumental in helping address the opioid crisis due to its ability to reverse the effects of an opioid overdose. Opioids include heroin and prescription pain pills like OxyContin, Percocet, methadone, and Vicodin.

Key Facts About Naloxone

When a person experiences an opioid overdose, their central nervous system and respiration system are depressed, and breathing slows down or stops. naloxone (Narcan™) medication blocks these effects and reverses the effects of an overdose. If given to one who has not taken opioids, it will not have any effect on them, since there are no opioids in their system to reverse. Naloxone also can’t get a person high.

Naloxone knocks the opioid off of the brain’s receptors and reverses the overdose

Frequently Asked Questions About Narcan™

Narcan™ and naloxone are the same. Narcan™ is a brand name for naloxone.

Yes. The American Medical Association (AMA) adopted new policies June 16, 2016 which encourage physicians to co-prescribe naloxone to patients at risk of an overdose as part of efforts to reverse the country’s opioid overdose epidemic. Also included in the new policy was; promote timely and appropriate access to non-opioid and non-pharmacologic treatments for pain; and support efforts to delink payments to health care facilities with patient satisfaction scores relating to the evaluation and management of pain.

Research studies have investigated this common concern and found that making naloxone available does NOT encourage people to use opioids more. The goal of distributing naloxone and educating people about how to prevent, recognize and intervene in overdoses is to prevent deaths. Other goals, such as decreasing drug use, can only be accomplished if the user is alive. Naloxone saves lives, giving the individual an opportunity to find recovery.

Aaron’s Law is designed to remove all barriers for an individual to assist a person experiencing an opioid-related overdose. Similar to immunity provided to those that administer CPR, use an AEDs, or use auto-injectable epinephrine, Aaron’s Law provides individuals or entities immunity from civil liability for obtaining naloxone, administering it in good faith, as long as the individual or entity does not act grossly negligent or commit willful misconduct.

Read Aaron’s Law overview from IUPUI Richard M. Fairbanks School of Public Health

A person experiencing an opioid overdose will be unresponsive to a sternal rub, can’t be awakened, can’t talk, may have pinpoint pupils, blueish lips or fingertips, vomiting, gurgling or choking noises, or have slow breath / respiration or heartbeat.

Naloxone can be given intravenously (IV), intramuscularly (IM) [injection into the muscle of the shoulder, thigh] or with an intranasal (IN) [sprayed up the nose]. Intranasal delivery eliminates the risk of needle stick injury and potential infectious disease exposure from IV or IM. Studies have found that intranasal delivery is equally effective to IM delivery. Learn more about how to administer naloxone.

Naloxone does not require a prescription and can be administered by anyone to someone that is experiencing an opioid overdose.

​Naloxone generally works within about 5 minutes. Repeated doses may be necessary if a person is still showing signs of overdose, hence why it is important to call 911.

There is no maximum dose for naloxone, so it can be given every 2 to 3 minutes until the person wakes up and breathes normally. It is recommended that a professional help in this situation.

Naloxone medication only affects people using opioids. If a person is not having an overdose but has been using opioids, naloxone will put them into immediate withdrawal, which can be very uncomfortable for the person but not life-threatening.

In the past, EMS protocols called for an initial dose of up to 5 times as powerful as that given in current Opioid Rescue kits. This increased the likelihood of immediate withdrawal symptoms when the person went from unconscious and near-death to stone-cold sober in a matter of seconds. Today, Opioid Rescue kits are designed to gradually revive a person by restoring breathing until medical personnel can arrive and takeover.

In the rare situation that someone is sensitive to naloxone, more than likely they will only experience a rash or other non-serious allergic reaction.

If a family member or bystander notices that a person’s breathing has slowed, stopped, or an overdose is suspected, naloxone can act as a bridge between the call to 911 and when help arrives to keep the person breathing. Every person responds differently to opioids and often the concentration of the opioid varies or is unknown. Based upon these variables a person may re-enter an overdose when the initial dose of naloxone wears off. Hence it is important that the individual receive medical attention as it can be life-threatening.

With all formulations of naloxone, it is important to check the expiration date (which can be found on the vial / tube) and make sure to keep it from light. Naloxone should not be exposed to extreme temperatures (read The effects of heat and freeze-thaw cycling on naloxone stability report).

*Naloxone expiration dates and storage conditions were updated on August 2020, for more details read Shelf Life Extension and Updated Storage Conditions and naloxone Potentially Viable Decades Past Expiration Date

Naloxone (Narcan™) Availability and Insurance Coverage

Pharmacist looking for prescription

Overdose Lifeline is registered to provide naloxone (Narcan™) kits, servicing a limited number of communities through donations and sponsorships. To request naloxone, please complete this form. To find naloxone near you, please view our naloxone boxes and distribution centers map.

How to Administer Naloxone

Naloxone is able to be administered through several different methods. Although traditionally naloxone was administered only by emergency response personnel, today it can be administered by minimally trained laypeople. Here you will find guides on how to administer naloxone for each method.

For more formal naloxone administration training, visit our Layperson naloxone Administration CE Course page.

Intramuscular naloxone should be injected into the shoulder or thigh at a 90-degree angle. It comes packaged in single and multi-dose forms.

Watch instructional video

Download instructional PDF

Most pharmacies carry the Amphastar brand of intranasal naloxone, which along with a MAD atomizer will convert the liquid to a nasal spray.

Watch instructional video

Download instructional PDF

Narcan® Nasal Spray Narcan® by Adapt Pharma is a 4mg formulation of intranasal naloxone. It requires no assembly which makes for easy use.

Watch instructional video

Download instructional PDF

Kloxxado™ by Hikma Pharmaceuticals PLC is an 8 mg formulation of intranasal naloxone. No assembly is required for use.

Download instructional PDF

Naloxone HCL is an FDA approved generic of Narcan®. 4 mg generic naloxone formulations are released by both Sandoz and Teva Pharmaceuticals USA, pharmaceutical companies specializing in generic medicines.

Download instructional PDF

Naloxone Laws in Your State

group opioid training on-site

Indiana Aaron’s Law (SEA-406)–named after Aaron Sims, who lost his life to heroin in 2013–allows layperson access to naloxone without a prescription, thus eliminating barriers to receiving the drug and using it to save lives. Effective 2015 and amended in 2016, Aaron’s Law means an individual, a family member, or friend can visit any Indiana pharmacy and request naloxone without prescription through a statewide standing order issued by the Indiana State Department of Health.

Learn More About Naloxone and the Opioid Crisis with our Online Courses

Learn at Your Own Pace
Fulfill Educational Requirements
Earn a Certificate upon Completion
From $15-45 per Course

Accredited through the Purdue University School of Pharmacy, Continuing Education Department.

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